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Enzalutamide vs. a Combination of Ra223 and Enzalutamide in Asymptomatic or Mildly Symptomatic Castration-Resistant Prostate Cancer Patients Metastatic to Bone (EORTC-1333-GUCG/PEACE III)

Curated by Clinicians: Educational Forum with Videos, Abstracts and Conference Information
Videos
Conference Coverage
Conference Highlights Written by Physician Scientists
Presented by Soichiro Yoshida, MD, PhD
The 2026 American Urologic Association (AUA) Annual Meeting featured an innovative presentation by Dr. Soichiro Yoshida evaluating the time-dependent overall survival benefit of enzalutamide plus radium-223 in men with metastatic castration-resistant prostate cancer (mCRPC) using reconstructed individual patient data (rIPD) from the EORTC 1333/PEACE-3 trial.
Presented by Michael Morris, MD
The 2026 PSMA & Beyond conference featured a clinical trial updates session and presentation by Dr. Michael Morris discussing DORA and PEACE-3 and the evolving role of radium-223.
Presented by Murilo de Almeida Luz, MD
The 2026 SESAUA annual meeting featured a prostate cancer session and presentation by Dr. Murilo de Almeida Luz discussing PSA and alkaline phosphatase decline in the EORTC PEACE-3 study evaluating the addition of radium-223 in metastatic castration resistant prostate cancer (mCRPC) starting enzalutamide.
Presented by Wei Chen, MD, MMed
The 2026 European Association of Urology (EAU) annual meeting featured an advancement in metastatic castration resistant prostate cancer (mCRPC) therapy session and a presentation by Dr. Wei Chen discussing a reconstructed analysis of the PEACE-3 trial assessing the time-dependent survival benefit of enzalutamide + radium-223 in mCRPC.
Presented by Enrique Gallardo, MD
 The 2026 GU ASCO annual meeting featured a prostate cancer session and a presentation by Dr. Enrique Gallardo discussing the final overall survival results from the EORTC 1333/PEACE-3 trial assessing enzalutamide with or without radium-223 in metastatic castration resistant prostate cancer (mCRPC).
Presented by Murilo de Almeida Luz, MD
The 2025 Western Section AUA annual meeting featured a prostate cancer session and a presentation by Murilo de Almeida Luz, MD, discussing the impact of bone-protecting agents on outcomes with enzalutamide, with or without radium-223, in asymptomatic/mildly symptomatic patients with bone mCRPC from PEACE-3. PEACE-3 was an ethics-approved international study in 446 patients with mCRPC and bone metastases randomized 1:1 to a combination of enzalutamide + radium-223 versus enzalutamide alone1:
Presented by Ronan Flippot, MD, MSc
Ronan Flippot, MD, MSc, discussed GETUG-AFU 43–PEACE8, a combination of darolutamide and stereotactic body radiation therapy in patients with castration resistant prostate cancer (CRPC) and oligometastases on functional imaging.
Presented by Michael Cookson, MD, FACS, MMHC
Michael Cookson, MD, FACS, MMHC, discussed PEACE-III, assessing enzalutamide versus a combination of radium-223 and enzalutamide in asymptomatic/mildly symptomatic patients with bone metastatic castration-resistant prostate cancer (mCRPC).
Presented by Andrey Soares, MD
The 2025 ASCO annual meeting featured a prostate cancer session and a presentation by Andrey Soares, MD, discussing PSA and alkaline phosphatase changes in the EORTC-1333 PEACE-3 study evaluating the addition of six cycles of radium 223 in metastatic castration-resistant prostate cancer (mCRPC) starting enzalutamide.
Presented by Fred Saad, MD, FRCS
The 2025 EAU annual meeting featured a prostate cancer session and a presentation by Dr. Fred Saad discussing a subgroup analysis of the PEACE 3 phase III trial assessing the impact of bone protecting agents on the efficacy and safety of enzalutamide versus combination of radium-223 and enzalutamide in asymptomatic or mildly symptomatic patients with bone metastatic castration-resistant prostate cancer (mCRPC). PEACE-3 was an international study in 446 patients with mCRPC and bone metastases randomized 1:1 to combination of enzalutamide and radium-223 versus enzalutamide alone:
Presented by Silke Gillessen Sommer, MD
(UroToday.com) The 2024 European Society for Medical Oncology (ESMO) Annual Congress held in Barcelona, Spain between September 13th and 16th, 2024 was host to a presidential symposium of practice-changing trials. Professor Silke Gillessen presented the initial results of EORTC-GUCG 1333/PEACE-3

Bayer will present new oncology data, including a late-breaking, comprehensive analysis from the Phase III ARANOTE trial investigating NUBEQA® (darolutamide) plus androgen deprivation therapy (ADT) in patients with metastatic hormone-sensitive prostate cancer (mHSPC), at the European Society for Medical Oncology (ESMO) Congress, taking place in Barcelona, Spain, from September 13-17, 2024.

Presented by Oliver Sartor, MD
The 2024 PSMA conference featured a presentation by Dr. Oliver Sartor discussing the role of radium-223 in the setting of PSMA PET. Dr. Sartor started by highlighting that based on the ALSYMPCA trial published in 2013,1 this was the first alpha emitter approved in all of medicine.
Presented by Silke Gillessen, MD
Bone strengthening agents such as bisphosphonates or the RANKL-targeting antibody denosumab reduced the bone loss associated with androgen deprivation therapy (ADT) and prevent skeletal-related events in castration resistant prostate cancer (CRPC). The use of these agents is recommended in CRPC by many guidelines.
Presented by Silke Gillessen, MD
Beginning with the introduction of docetaxel for metastatic castration resistant prostate cancer (mCRPC) in 2004, there has been a dramatic and rapid proliferation of systemic therapy options in advanced prostate cancer including a number of novel hormonal therapies (including abiraterone acetate and enzalutamide),
Presented by Bertrand F. Tombal, MD, PhD
Skeletal fractures, pathological or not, are a frequent and underestimated side-effect of systemic treatment of metastatic castration-resistant prostate cancer (mCRPC). The ERA223 trial randomized 806 patients with chemotherapy-naïve, mCRPC with bone metastasis to radium-223 or placebo, in addition to abiraterone acetate.
Presented by Bertrand Tombal, MD, PhD
Dr. Bertrand Tombal and colleagues presented the trial design for PEACE III, enzalutamide vs. a combination of radium-223 (Ra-223) and enzalutamide in asymptomatic or mildly symptomatic CRPC patients metastatic to bone. The α-emitting radiopharmaceutical Ra-223 reduced the risk of death by 30% vs placebo in the phase III ALSYMPCA trial.1