OBJECTIVES: New-onset diabetes mellitus after transplant is a common complication in renal allograft recipients.
Recently, a high prevalence of diabetes mellitus has been reported in patients with chronic hepatitis C virus. The association between hepatitis C and diabetes mellitus is well demonstrated in the general population, but some controversy still exists. This work aimed to study the effect of pretransplant hepatitis C virus on the development of new-onset diabetes mellitus after transplant in Egyptian living-donor renal allotransplant recipients.
MATERIALS AND METHODS: This retrospective single center study included 913 kidney transplant recipients who were transplanted at Mansoura Urology and Nephrology Center between 2000 and 2010. The patients were divided into 4 groups according to their hepatitis C virus serology and diabetic status.
RESULTS: Pretransplant dialysis duration and number of blood transfusion units were statistically significant among both viremic and nonviremic groups. With respect to induction therapy, a highly statistical significance was observed between the 4 groups regarding presence and type of adjuvant therapy (P < .001). With respect to maintenance immunosuppression, high statistically significant results were observed regarding steroid and rapamycin between the 4 groups (P < .001) with lower significance regarding mycophenolate mofetil (P = .04) but no significance regarding azathioprine, cyclosporine, or tacrolimus therapy. Incidence of new-onset diabetes mellitus after transplant was statistically higher in the viremic than nonviremic group (P < .001).
CONCLUSIONS: There was a positive correlation between incidence of new-onset diabetes mellitus after transplant and positive pretransplant hepatitis C virus status.
Written by:
Abbas MH, Ismail MI, El Deeb SA, Nagib AM, Hassan NM, Refaie AF, El Maghrabi HM, Denewar AA, Bakr MA. Are you the author?
Department of Dialysis and Transplantation, The Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Reference: Exp Clin Transplant. 2015 Feb;13(1):26-34.
doi: 10.6002/ect.2014.0090
PubMed Abstract
PMID: 25654411