To understand the influence of histologic subtypes on the survival outcomes of intermediate-high and high-risk renal cell carcinoma (RCC) following nephrectomy METHODS: This study employed data files from the SEER Program to identify patients diagnosed with intermediate-high or high risk RCC and treated with nephrectomy. Unadjusted Kaplan Meier curves, and multivariable Cox regression analyses were applied to estimate the hazards of histologic types for overall survival (OS) and cancer-specific survival (CSS).
OS was higher for chromophobe (HR=0.58, 95% CI 0.47-0.70; p<0.0001), similar for papillary (HR=0.90, 95% CI 0.80-1.02; p=0.11) and worse for sarcomatoid (HR=3.17, 95% CI 2.70-3.72; p<0.0001) subtypes relative to the clear cell subtype. OS was lower in the high-risk disease (HR=2.35, 95% CI 2.01-2.74; p <0.0001) versus intermediate-high risk disease. CSS was higher for chromophobe (HR=0.47, 95% CI 0.35-0.63; p<0.0001), similar for papillary (HR=0.91, 95% CI 0.77-1.08; p=0.28) and worse for sarcomatoid (HR=4.19, 95% CI 3.50-5.02; p<0.0001) subtypes relative to the clear cell subtype. CSS was lower for the high-risk disease (HR=2.86, 95%CI 2.39-3.43; p <0.0001) relative to intermediate-high risk disease.
Urology. 2021 Sep 04 [Epub ahead of print]
Joshua Ikuemonisan, Adeniyi Togun, Isaac Oyejinmi, Adetunji Bakare, Oluwakayode Adejoro
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55414, USA. Electronic address: ., School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA., Park-Nicollet Methodist Hospital, 6600 Excelsior Boulevard, St Louis Park, MN 55426, USA., Janssen LLC, 800 Ridgeview Dr, Horsham, PA 19044, USA.