Survival patterns in squamous cell carcinoma of the penis (SCCP) have been described in several studies. However, the years of life lost (YLL) among patients with SCCP compared to the general population have not been quantified.
Within the SEER database (2004-2021), SCCP patients aged 40-75 years were included. SCCP patients were stratified according to stage at diagnosis in localized (T1-2, N0, M0), regional (T3-4, anyN, M0; anyT, N +, M0), and metastatic (anyT, anyN, M1). For each patient, an age- and sex-mathced control was generated from Social Security Administration life tables using Monte Carlo simulation. Subsequently, the average YLL until the age of 75 years between SEER patient cases and simulated controls were quantified using the Kaplan-Meier methodology.
Overall, 1666 (64.9%) localized, 505 (28.1%) regional and 123 (7.0%) metastatic SCCP patients were included. Relative to population controls, SCCP patients of all-stages exhibited 4.4 YLL (p < 0.001). In subsequent stage stratified analyses YLL values were 3.0 vs. 6.0 vs. 10.7 YLL (p < 0.001) for respectively localized, regional and metastatic SCCP subgroups.
In general SCCP patients are at 4.4 YLL relative to population controls, the latter may reach 10.7 YLL when metastatic stage at presentation is diagnosed.
World journal of urology. 2026 Apr 11*** epublish ***
Federico Polverino, Calogero Catanzaro, Michele Nicolazzini, Michele Petix, Leonardo Quarta, Maximilian Filzmayer, Jordan A Goyal, Massimiliano Creta, Simone Morra, Gianluigi Califano, Claudia Collà Ruvolo, Alberto Briganti, Felix K H Chun, Carlotta Palumbo, Riccardo Schiavina, Gennaro Musi, Shahrokh F Shariat, Fred Saad, Nicola Longo, Pierre I Karakiewicz
Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada. ., Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada., Department of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, Naples, Italy., Vita-Salute San Raffaele University, Milan, Italy., Department of Urology, Goethe University, University Hospital, FrankfurtFrankfurt Am Main, Germany., Division of Urology, Department of Translational Medicine, University of Eastern Piedmont, Maggiore Della Carità Hospital, Novara, Italy., Division of Urology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy., Department of Urology, IEO European Institute of Oncology, IRCCS, Via Ripamonti 435, Milan, Italy., Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.