The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) is undertaking a new cohort study in LURN II including cases and controls.
This new cohort was enrolled to specifically study urinary urgency and urgency urinary incontinence, lower urinary tract symptoms (LUTSs) that are often difficult to treat due to a lack of understanding of their phenotypes and pathophysiologies.
This paper will focus on the motivation for the second iteration of LURN and highlight the new research techniques and plans for more thorough phenotyping of this population.
This paper will outline the gaps in understanding in treating LUTSs, specifically urinary urgency.
Neurourology and urodynamics. 2024 Jul 29 [Epub ahead of print]
Anne P Cameron, Claire C Yang, Catherine S Bradley, James W Griffith, Ziya Kirkali, J Quentin Clemens, Karl J Kreder, Kimberly S Kenton, Victor P Andreev, Cindy L Amundsen, J Eric Jelovsek, Brian T Helfand, H Henry Lai, LURN Study Group
Michigan Medicine Urology, University of Michigan, Ann Arbor, Michigan, USA., Department of Urology, University of Washington, Seattle, Washington, USA., Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA., Biological Sciences Division, The University of Chicago, Chicago, Illinois, USA., National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA., Department of Urology, University of Michigan, Ann Arbor, Michigan, USA., Department of Urology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois, USA., Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA., Obstetrics and Gynecology, Division of Urogynecology and Reconstructive Pelvic Surgery, Division of Urology, Female Pelvic Medicine and Reconstructive Surgery, Duke University School of Medicine, Duke Health, Raleigh, North Carolina, USA., Obstetrics and Gynecology, Duke University School of Medicine, Duke Health, Raleigh, North Carolina, USA., Department of Urology, NorthShore University HealthSystem, Glenview, Illinois, USA., Division of Urologic Surgery, Departments of Surgery and Anesthesiology, Washington University in St. Louis, St. Louis, Missouri, USA.