Our recent study, published in International Urology and Nephrology, highlighted the outcomes of intra-detrusor injections of amnion/chorion (AC) in fifteen patients with IC/BPS who had previously not responded to other therapies. We noted that at the 6-month follow-up, improvement in voiding symptoms and bladder pain was achieved and sustained in all fifteen patients.
As AC offers capabilities of wound healing in many other fields of medicine, likewise amniotic bladder therapy (ABT) may offer the capability of urothelial healing in IC/BPS.
Under general anesthesia, 15 consecutive IC/BPS patients received intra-detrusor injections of 100 mg AC diluted in 20 ml 0.9% preservative-free sodium chloride. Clinical evaluation and questionnaires Interstitial Cystitis Symptom Index (ICSI), Interstitial Cystitis Problem Index (ICPI), Bladder Pain/ Interstitial Cystitis Symptom Score (BPIC-SS), Overactive Bladder Assessment Tool) were repeated at pre-op and 2, 4, 8 12, and 24 weeks post-op.
Our findings suggest that ABT using AC formulation may improve symptoms for some refractory IC/BPS patients for up to 6 months. Further studies are needed to correlate these results and assess safety in larger patient cohorts.
Written by: Kyle O'Hollaren,1 Jack Considine,1 Codrut Radoiu,1 Raghav Madan,1 Aron Liaw,1,2 Nivedita Dhar,2,3
- Wayne State University School of Medicine, Detroit, MI
- John D. Dingell VA Medical Center, Detroit, MI,
- Detroit Medical Center, Detroit, MI