To assess the efficacy and safety of Flower Pollen Extract with Vitamins (PEV) in improving urinary and sexual function in men diagnosed with chronic prostatitis (CP).
A retrospective controlled study was conducted involving 145 men with CP. Participants were divided into two groups: the intervention group received PEV (n=71) and the control group received ibuprofen (n=74). Clinical and functional outcomes were evaluated at baseline and at 1, 3, and 12 months post-treatment.
Both groups exhibited comparable baseline characteristics. At 3 months, the PEV group demonstrated significantly greater improvement in IPSS (9.4 ± 2.7 vs. 10.3 ± 2.6, p=0.04), NIH-CPSI (11.5 ± 3.7 vs. 13.6 ± 4.2, p=0.002), and IIEF-5 (19.8 ± 3.6 vs. 17.7 ± 3.3, p<0.001). These benefits were maintained and further enhanced at 12 months, with mean IPSS 7.6 ± 2.1, NIH-CPSI 6.5 ± 2.4, and IIEF-5 21.6 ± 3.3 in the PEV group (all p<0.005). No significant differences were observed in Qmax.
Long-term PEV therapy significantly improves urinary and sexual function in men with CP compared with ibuprofen treatment, demonstrating sustained, time-dependent efficacy and excellent safety.
Journal of basic and clinical physiology and pharmacology. 2025 Dec 25 [Epub ahead of print]
Carlo Giulioni, Valentina Maurizi, Federico Falsetti, Felice Crocetto, Angelo Cafarelli
Department of Urology, 47131 Casa di Cura Villa Igea , Ancona, Italy., Internal Medicine Unit Jesi, Jesi, Italy., Department of Precision and Regenerative Medicine and Ionian Area-Urology, Division of Urology, Andrology and Kidney Transplantation Unit, University of Bari "Aldo Moro", Bari, Italy., Department of Neurosciences and Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Naples, Italy.