Condition: Prostate Cancer, Sarcopenia

Study Type: Interventional

Clinical Trials Identifier NCT 8-digits: NCT07463092

Sponsor: University of Sao Paulo

Eligibility:

• Age: minimum 40 Years maximum N/A
• Gender: Male

Inclusion Criteria:

• Men aged ≥ 40 years;
• Patients with histologically or cytologically confirmed localized prostate cancer;
• Patients who have undergone surgical castration or pharmacological castration with gonadotropin-releasing hormone (GnRH/LHRH) agonists or antagonists for at least six months prior to the start of the intervention;
• Patients receiving continuous or intermittent androgen deprivation therapy;
• Patients with an Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2;
• Not engaged in resistance training in the three months prior to the intervention;
• Not using creatine supplementation in the three months prior to the intervention;
• Willing to participate in a 12-week intervention consisting of resistance training performed three times per week and daily supplementation with creatine monohydrate or maltodextrin.

Exclusion Criteria:

• Patients with insulin-dependent diabetes mellitus;
• Patients with dialysis-dependent renal failure;
• Patients with severe chronic liver disease;
• Estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m²;
• Any hormonal treatment outside that established by the medical team;
• Patients planning to undergo chemotherapy within the next six months.

View trial on ClinicalTrials.gov