Condition: Bladder Cancer, Liquid Biopsy, Repeat Transurethral Resection of Bladder Tumor

Study Type: Interventional

Clinical Trials Identifier NCT 8-digits: NCT07187635

Sponsor: Tianjin Medical University Second Hospital

Eligibility:

• Age: minimum 18 Years maximum N/A
• Gender: All

Inclusion Criteria:

1. Participants must meet all of the following criteria to be eligible for the study:
2. Male or female, aged 18 years or older.
3. Histologically confirmed non-muscle-invasive bladder tumor, with no evidence of muscle-invasive bladder cancer or metastatic disease.
4. Histologically confirmed urothelial carcinoma of the bladder or bladder tumor with urothelial carcinoma as the predominant component (>50%).
5. At least one of the following conditions:
6. Incomplete initial transurethral resection of bladder tumor (TURBT) or suspected incomplete resection.
7. Absence of detrusor muscle in the initial TURBT pathological specimen (except for low-grade Ta stage tumors or carcinoma in situ [CIS]).
8. T1 stage tumor.
9. Willingness to provide a 50 mL urine sample between 2-6 weeks after the initial TURBT and prior to re-TURBT.
10. Willingness to provide tumor tissue samples for pathological examination.
11. Willingness to undergo genetic testing required for the trial.

Exclusion Criteria:

1. Contraindications to transurethral resection of bladder tumor (TURBT).
2. Concurrent malignancy of the upper urinary tract (ureter or renal pelvis).

View trial on ClinicalTrials.gov