Urinary tract infections represent nearly 40% of all healthcare-associated infections where the vast majority are related to indwelling catheter use. Over 900,000 patients develop a catheter-associated urinary tract infection (CAUTI) each year while in a US hospital, making this an important patient safety issue. It has been estimated that as many as 65 to 70% of cases of CAUTIs may be preventable if evidence-based prevention strategies are applied. The CAUTI Challenge website provides comprehensive resources for preventing CAUTI and reducing indwelling urinary catheter use.