Testicular Cancer
Long-Term Clinical Outcomes of Advanced Germ Cell Tumors: Experience From 105 Patients Over 20 Years.
- Details
Limited data on metastatic germ cell tumors are available in Japan. We aimed to evaluate the long-term cancer-specific mortality of advanced germ cell tumors.
We present the clinical outcomes of 105 patients with mediastinal or metastatic germ cell tumors, including 33 seminoma and 72 non-seminoma, who received induction cisplatin-based chemotherapy at our hospital between September 2002 and February 2025.
Contemporary Perioperative Outcomes of Robotic Retroperitoneal Lymph Node Dissection for Testicular Cancer.
- Details
Robotic retroperitoneal lymph node dissection (R-RPLND) is increasingly recognized as a treatment option for testicular cancer. This study reports contemporary perioperative outcomes from a single institution and examines national trends in R-RPLND adoption.
NFL's Alex Singleton and the Testicular Cancer Detection Gap.
- Details
In November 2025, Denver Broncos linebacker Alex Singleton's accidental testicular cancer diagnosis through routine drug testing highlighted a critical gap in detection guidance for young men. Despite being the most common malignancy among males aged 15 to 44, the United States Preventive Services Task Force maintains a D recommendation against testicular self-examination (TSE), effectively discouraging awareness and discussion.
Improving the Understanding of Late Effects of Testicular Cancer in Adolescent and Young Adult Survivors: TRANSCEND-XR.
- Details
Testicular cancer (TC) is the most common malignancy amongst adolescents and young adults (AYAs) aged 15-39 years assigned male at birth. Survivors often experience late effects of treatment and report unmet supportive care needs.
Primary retroperitoneal lymph node dissection for clinical stage II seminoma: Comparative analysis against established paradigms using the National Cancer Data Base.
- Details
This paper aims to perform a comparative, real-world analysis of outcomes after primary retroperitoneal lymph node dissection (pRPLND) for clinical stage II (CSII) seminoma.
Using the National Cancer Data Base, we identified patients with CSII germ cell tumours (GCT) between 2004 and 2022.
Residence Near Agricultural Crops at Birth and Risk of Adult Testicular Germ Cell Tumors: A French Nationwide Case-Control Study Using Historical Aerial GIS Data.
- Details
Early life exposure to pesticides, in particular through pesticides drift in residents nearby agricultural crops, is suspected to increase testicular germ cell tumors (TGCT) risk. We conducted a hospital-based case-control study of 472 TGCT cases and 683 matched controls aged 18-45 years in France and estimated adult TGCT risk associated with agricultural surfaces around residence as a surrogate for environmental exposure to agricultural pesticides at time of birth.
How to Optimize Treatment for Patients With Poor-Risk Testicular Cancer.
- Details
Male germ cell tumors, of which testicular is the most common, are rare but generally highly curable malignancies. Cure rates in the metastatic setting are among the highest for any solid tumor, although outcomes in the poor-risk subgroup remain suboptimal.
Robotic retroperitoneal lymph node dissection: a stepwise technical guide.
- Details
Retroperitoneal lymph node dissection remains a critical operation in selected patients with testicular cancer, including defined settings of early metastatic disease, post-chemotherapy residual masses, and emerging indications for primary retroperitoneal lymph node dissection in low-volume seminoma.
TNFSF10: a promising prognostic biomarker and therapeutic target for immunotherapy in testicular germ cell tumors.
- Details
Testicular germ cell tumors (TGCTs) are malignant neoplasms with a poor prognosis, and the absence of reliable biomarkers for patient stratification and diagnosis presents a significant challenge.
We employed an integrated analysis of Single-Cell RNA-Sequencing and TCGA data to evaluate TNFSF10 as a potential biomarker for prognosis and immunotherapy in TGCTs.
Lipidomic Plasticity in Testicular Cancer Reflects Diagnostic Signatures in Tissue and Plasma: A Pilot Study.
- Details
Diagnosis and prognosis of testicular cancer remain challenging due to lack of reliable diagnostic markers. While lipidomic alterations have been explored in other cancers, their application to testicular cancer is limited.