Systemic Therapy in Patients With Metastatic Castration-Resistant Prostate Cancer: ASCO Living Guideline, Version 2026.1.

Living guidelines are developed for selected topic areas with rapidly evolving evidence that drives frequent change in recommended clinical practice. Living guidelines are updated on a regular schedule by a standing expert panel that systematically reviews the health literature on a continuous basis, as described in the ASCO Guidelines Methodology Manual. ASCO Living Guidelines follow the ASCO Conflict of Interest Policy Implementation for Clinical Practice Guidelines. Living Guidelines and updates are not intended to substitute for independent professional judgment of the treating clinician and do not account for individual variation among patients. See appendix for disclaimers and other important information (Appendix 1 and Appendix 2). Updates are published regularly and can be found at www.asco.org/genitourinary-cancer-guidelines.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2026 Jan 20 [Epub ahead of print]

Mary-Ellen Taplin, Irbaz Bin Riaz, R Bryan Rumble, Syed Arsalan Ahmed Naqvi, Thomas A Hope, Mariane Fontes Dias, Huan He, Sebastien J Hotte, Hamid Emamekhoo, M Hassan Murad, Paul Celano, Terry M Kungel, Steve Hentzen, Michael Thomas Serzan, Rahul A Parikh

Dana-Farber Cancer Institute, Boston, MA., Mayo Clinic, Phoenix, AZ., American Society of Clinical Oncology, Alexandria, VA., University of California San Francisco, San Francisco, CA., Oncoclinicas&Co-Medica Scientia Innovation Research (MEDSIR), Latin America Cooperative Group (LACOG)-Genito-Urinary, Rio de Janeiro, Brazil., Yale University, New Haven, CT., McMaster University, Hamilton, ON, Canada., University of Wisconsin, Madison, WI., Mayo Clinic, Rochester, MN., Greater Baltimore Medical Center (GBMC), Towson, MD., Woolwich, ME., Leawood, KS., University of Kansas Medical Center, Westwood, KS.