Contribution of the Microbiome to Interstitial Cystitis/Bladder Pain Syndrome: A Mini Review

In the present study, we reviewed 12 studies from the past 10 years on the human microbiome for patients with interstitial cystitis/bladder pain syndrome (IC/BPS). This review highlights the multifaceted role of the microbiome in IC/BPS, emphasizing its contributions to inflammation, metabolic dysfunction, and symptomatology.

Consistent associations between microbial shifts and inflammatory pathways offer a robust basis for future research. However, discrepancies in microbial diversity metrics and taxa identification underscore the need for standardized methodologies and larger, more diverse cohorts. Integration of microbiome and metabolome analyses holds significant promise for uncovering novel diagnostic biomarkers and therapeutic strategies and paving the way for precision medicine approaches in IC/BPS management.

In general, Studies have revealed significant changes in microbial species for these patients, especially in urine. However, research on whether IC/BPS can be treated with interventions to modify microbial communities in the body is still needed.

Written by: Ninghan Feng, Medical School of Nantong University, Nantong, China; Department of Urology, Jiangnan University Medical Center, Wuxi, China

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