BACKGROUND: Indications of dialysis treatment for patients with end-stage renal disease depend on various clinical and laboratory parameters.
In this study, we aimed to determine whether standardized serum cystatin C (SCC) equation may be an applicability of marker for dialysis initiation and its relationship to other clearance values among patients with advanced chronic kidney disease.
MATERIALS AND METHODS: A total of 84 patients (45 males, 39 females) aged 19-89 were evaluated in this study. Hemodialysis was indicated according to clinical and laboratory findings, and estimated glomerular filtration rate (eGFR) was according to four different formulas [MDRD, EpiCKD, Cockcroft Gault formula (CGF) and SCC equation].
RESULTS: eGFR values of patients in the study were 7.23 ± 3.26, 7.86 ± 3.78, 15.09 ± 10.88 and 11.31 ± 4.54 according to MDRD, EpiCKD, SCC equation and CGF, respectively. There was a positive correlation between MDRD, EpiCKD and CGF, and between EpiCKD and CGF (p < 0.01). Also, statistically significant correlation was found between SCC equation and CGF (p < 0.05).
CONCLUSION: SCC equation was not seemed to be an appropriate marker for starting dialysis in patients with advanced CKD.
Written by:
Sit D, Basturk T, Yildirim S, Karagoz F, Bozkurt N, Gunes A. Are you the author?
Clinic of Internal Medicine/Nephrology, Bagcilar Training and Research Hospital, 34200, Bagcılar, Istanbul, Turkey.
Reference: Int Urol Nephrol. 2013 Jun 8. Epub ahead of print.
doi: 10.1007/s11255-013-0481-4
PubMed Abstract
PMID: 23749031
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